ARG-RHE / ARG-LMM

ARG-RHE provides efficient variance component analysis based on Ancestral Recombination Graphs (ARGs). It is implemented in the ARG-LMM package, which also includes additional fast ARG-based linear mixed model methods.

Links

• User manual
• PyPI
• Source (GitHub)

Paper

Leveraging ancestral recombination graphs for scalable mixed-model analysis of complex traits. J. Zhu, G. Kalantzis, A. Pazokitoroudi, Á. Gunnarsson, H. Loya, H. Chen, S. Sankararaman, P. Palamara. Cell Genomics. 2025. [paper]