ARG-Needle is an algorithm to reconstruct the genealogical history (ancestral recombination graph, ARG) of large collections of sequenced or genotyped genomes. ARG-Needle-lib is a library that can be used to perform genealogy-wide association and other analyses. This package also implements the ASMC-clust ARG reconstruction algorithm described in the manuscript.


Biobank-scale inference of ancestral recombination graphs enables genealogical analysis of complex traits. B. C. Zhang, A. Biddanda, Á. F. Gunnarsson, F. Cooper, P. F. Palamara. Nature Genetics. May 2023. [paper]